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Cheap flights from Frankfurt am Main Airport to Panama City from £341

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
FRA — PTY
1 Jun — 8 Jun1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Frankfurt to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Frankfurt to Panama City
Explore the most affordable flight options available from Frankfurt to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 2 May 2026.

Thu 5/1110:45
FRA
-
PTY
1 stop15h 00m
Air Europa
Mon 16/1121:30
PTY
-
FRA
1 stop14h 20m
Air Europa
Deal found 30/4£568
Thu 5/1110:45
FRA
-
PTY
1 stop15h 00m
Air Europa
Sun 22/1121:30
PTY
-
FRA
1 stop14h 20m
Air Europa
Deal found 1/5£568
Thu 5/1110:45
FRA
-
PTY
1 stop15h 00m
Air Europa
Thu 12/1121:30
PTY
-
FRA
1 stop30h 15m
Air Europa
Deal found 30/4£574
Tue 3/1119:05
FRA
-
PTY
1 stop30h 40m
Air Europa
Thu 19/1121:30
PTY
-
FRA
1 stop14h 20m
Air Europa
Deal found 30/4£576
Fri 6/1119:05
FRA
-
PTY
1 stop30h 40m
Air Europa
Sun 22/1121:30
PTY
-
FRA
1 stop14h 20m
Air Europa
Deal found 1/5£576
Sun 7/610:15
FRA
-
PTY
2 stops16h 30m
Multiple Airlines
Tue 23/621:55
PTY
-
FRA
1 stop33h 25m
Multiple Airlines
Deal found 2/5£579
Tue 3/1119:05
FRA
-
PTY
1 stop30h 40m
Air Europa
Sat 14/1121:30
PTY
-
FRA
1 stop30h 15m
Air Europa
Deal found 30/4£582
Sun 14/618:30
FRA
-
PTY
1 stop32h 15m
Multiple Airlines
Sun 21/611:46
PTY
-
FRA
3 stops27h 14m
Multiple Airlines
Deal found 30/4£586
Thu 5/1110:45
FRA
-
PTY
1 stop15h 00m
Air Europa
Wed 18/1121:30
PTY
-
FRA
1 stop14h 20m
Air Europa
Deal found 30/4£593
Sat 31/1010:45
FRA
-
PTY
1 stop15h 00m
Air Europa
Thu 12/1121:30
PTY
-
FRA
1 stop14h 20m
Air Europa
Deal found 28/4£595
Mon 14/914:15
FRA
-
PTY
1 stop33h 35m
Multiple Airlines
Mon 28/914:21
PTY
-
FRA
1 stop35h 34m
Multiple Airlines
Deal found 28/4£598
Fri 30/1019:05
FRA
-
PTY
1 stop30h 40m
Air Europa
Mon 9/1121:30
PTY
-
FRA
1 stop14h 20m
Air Europa
Deal found 1/5£601

Find flight deals from Frankfurt to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Frankfurt (FRA) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 2 May 2026.

Round-trip from

£579

One-way from

£341

Popular in

December

Cheapest in

June

Average price

£558
Air France
  • Air France
  • 7/6-23/6
  • 3 total stops
  • 49h 55m total
  • Frankfurt am Main to Panama City
Search Deals
Air Europa
  • Air Europa
  • 10/5
  • 1 total stop
  • 14h 45m total
  • Frankfurt am Main to Panama City
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£18 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Frankfurt to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 2 May 2026.
Use the filters below to find and compare flights from Frankfurt am Main Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 22/10

06:35-19:31

2 stops19h 56m

Panama City Tocumen Intl

Sat 31/10

15:41-06:35

2 stops32h 54m

£613
Fastest return journey

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 4/6

07:45-19:31

2 stops18h 46m

Panama City Tocumen Intl

Sun 14/6

09:45-12:10

2 stops19h 25m

£615

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 11/6

06:35-19:31

2 stops19h 56m

Panama City Tocumen Intl

Tue 25/8

22:55-09:10

1 stop27h 15m

£615

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Mon 14/9

11:25-19:31

2 stops39h 06m

Panama City Tocumen Intl

Mon 28/9

09:45-09:10

1 stop16h 25m

£617

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sat 1/8

11:10-04:04

1 stop23h 54m

Panama City Tocumen Intl

Fri 21/8

10:00-11:15

1 stop18h 15m

£619

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sat 11/7

17:10-14:14

2 stops28h 04m

Panama City Tocumen Intl

Thu 30/7

09:45-12:10

2 stops19h 25m

£619

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sat 11/7

10:30-04:04

2 stops24h 34m

Panama City Tocumen Intl

Wed 29/7

09:45-12:10

2 stops19h 25m

£619

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Mon 17/8

12:20-04:04

2 stops22h 44m

Panama City Tocumen Intl

Tue 1/9

09:45-12:10

2 stops19h 25m

£620

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sun 16/8

11:10-04:04

1 stop23h 54m

Panama City Tocumen Intl

Mon 7/9

10:00-11:15

1 stop18h 15m

£620

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Fri 14/8

10:15-04:04

2 stops24h 49m

Panama City Tocumen Intl

Mon 7/9

09:45-09:10

1 stop16h 25m

£620

Flights are sorted by cheapest return flights first.

Deals found on 29/4

Showing 1-10 of 15 resultsSorted by cheapest first
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Best time to book a flight from Frankfurt to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Frankfurt with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Frankfurt am Main Airport to Panama City

How far ahead should I book a flight from Frankfurt am Main Airport to Panama City?

To ensure you get the cheapest price possible for a flight from Frankfurt am Main Airport to Panama City, you should look to book at least 62 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Frankfurt am Main Airport to Panama City?

Currently, June is the cheapest month in which you can book a flight from Frankfurt am Main Airport to Panama City (average of £493). Flying from Frankfurt am Main Airport to Panama City in December is currently the most expensive (average of £675). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Frankfurt am Main Airport to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Frankfurt to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Frankfurt am Main?

    For a flight from Frankfurt am Main to Panama City, you will be flying into Tocumen Intl. Panama City Tocumen Intl (PTY) is just 11.4 mi from the center of the city. Tocumen Intl is the only Panama City airport and it handles 0 inbound flights from Frankfurt am Main per day. 0 airlines have flights to Panama City Tocumen Intl from Frankfurt am Main on a regular basis.

  • How long is the flight from Frankfurt am Main Airport to Panama City?

    Departing from Frankfurt am Main Airport to Panama City will take you 19h 56m. Airlines will cover a distance of 5644 mi.

  • Can I find deals for flights from Frankfurt to Panama City that include hotel bookings?

    Yes. In addition to deals on Frankfurt to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Frankfurt to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Frankfurt to Panama City.

  • Can I find deals for business class flights from Frankfurt to Panama City?

    Yes. Cheapflights offers flight deals from Frankfurt to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Frankfurt am Main Airport to Panama City?

    Currently, June is the cheapest month in which you can book a flight from Frankfurt am Main Airport to Panama City (average of £493). Flying from Frankfurt am Main Airport to Panama City in December is currently the most expensive (average of £675). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Why should you use Cheapflights to find cheap flight tickets from Frankfurt to Panama City?

Millions of users choose and trust Cheapflights to book the best flight deals from Frankfurt to Panama City for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Frankfurt to Panama City with no change fees?

Yes! Cheapflights helps users easily find flights from Frankfurt to Panama City with no change fees.

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Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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