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Cheap flights from Frankfurt am Main Airport to Panama City from £499

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
FRA — PTY
24 Jul — 31 Jul1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Frankfurt to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Frankfurt to Panama City
Explore the most affordable flight options available from Frankfurt to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 24 June 2026.

Thu 3/910:15
FRA
-
PTY
2 stops16h 30m
Multiple Airlines
Tue 29/921:55
PTY
-
FRA
1 stop17h 10m
Multiple Airlines
Deal found 20/6£600
Sat 31/1018:30
FRA
-
PTY
2 stops31h 50m
Multiple Airlines
Fri 20/1122:30
PTY
-
FRA
1 stop17h 35m
Multiple Airlines
Deal found 24/6£601
Mon 7/910:55
FRA
-
PTY
1 stop14h 45m
Air Europa
Thu 1/1020:25
PTY
-
FRA
1 stop14h 25m
Air Europa
Deal found 23/6£611
Mon 5/1010:55
FRA
-
PTY
1 stop14h 45m
Air Europa
Wed 21/1020:25
PTY
-
FRA
1 stop14h 25m
Air Europa
Deal found 23/6£612
Sat 31/1018:30
FRA
-
PTY
2 stops31h 50m
Multiple Airlines
Sun 22/1115:30
PTY
-
FRA
2 stops19h 15m
Multiple Airlines
Deal found 24/6£613
Thu 29/1010:15
FRA
-
PTY
1 stop16h 05m
Multiple Airlines
Sun 8/1122:30
PTY
-
FRA
2 stops17h 55m
Multiple Airlines
Deal found 23/6£614
Wed 28/1006:55
FRA
-
PTY
2 stops19h 25m
Multiple Airlines
Sat 7/1115:21
PTY
-
FRA
2 stops19h 24m
Multiple Airlines
Deal found 20/6£615
Sat 4/713:00
FRA
-
PTY
2 stops22h 04m
United Airlines
Thu 23/722:55
PTY
-
FRA
2 stops25h 25m
United Airlines
Deal found 24/6£617
Fri 25/907:00
FRA
-
PTY
2 stops19h 45m
KLM
Fri 9/1021:55
PTY
-
FRA
2 stops17h 05m
KLM
Deal found 23/6£617
Thu 10/907:45
FRA
-
PTY
2 stops18h 46m
United Airlines
Tue 29/915:30
PTY
-
FRA
1 stop33h 45m
United Airlines
Deal found 23/6£619
Sun 13/919:10
FRA
-
PTY
1 stop30h 30m
Air Europa
Mon 5/1020:25
PTY
-
FRA
1 stop14h 25m
Air Europa
Deal found 23/6£620

Find flight deals from Frankfurt to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Frankfurt (FRA) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 24 June 2026.

Round-trip from

£600

One-way from

£499

Popular in

June

Cheapest in

September

Average price

£708
Air France
  • Air France
  • 3/9-29/9
  • 3 total stops
  • 33h 40m total
  • Frankfurt am Main to Panama City
Search Deals
KLM
  • KLM
  • 2/12
  • 2 total stops
  • 19h 25m total
  • Frankfurt am Main to Panama City
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£24 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Frankfurt to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 24 June 2026.
Use the filters below to find and compare flights from Frankfurt am Main Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 9/7

07:45-19:31

2 stops18h 46m

Panama City Tocumen Intl

Tue 21/7

09:45-09:10

1 stop16h 25m

£617

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Fri 10/7

07:45-04:04

2 stops27h 19m

Panama City Tocumen Intl

Tue 14/7

07:55-08:15

1 stop17h 20m

£617
Fastest return journey

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 24/9

07:45-19:31

2 stops18h 46m

Panama City Tocumen Intl

Mon 28/9

09:45-07:35

1 stop14h 50m

£619

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 23/7

13:00-04:04

2 stops22h 04m

Panama City Tocumen Intl

Thu 30/7

09:45-12:10

2 stops19h 25m

£619

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sun 13/9

19:10-18:40

1 stop30h 30m

Panama City Tocumen Intl

Fri 2/10

20:25-17:50

1 stop14h 25m

£620

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sun 19/7

07:45-04:04

2 stops27h 19m

Panama City Tocumen Intl

Fri 14/8

22:55-09:10

1 stop27h 15m

£620

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Tue 21/7

07:45-04:04

2 stops27h 19m

Panama City Tocumen Intl

Mon 17/8

22:55-06:50

2 stops24h 55m

£620

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Fri 18/9

07:45-19:31

2 stops18h 46m

Panama City Tocumen Intl

Fri 25/9

09:45-09:10

1 stop16h 25m

£620

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sun 23/8

07:45-04:04

2 stops27h 19m

Panama City Tocumen Intl

Mon 7/9

10:00-11:15

1 stop18h 15m

£620

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Fri 17/7

09:45-04:04

2 stops25h 19m

Panama City Tocumen Intl

Thu 30/7

09:45-12:10

2 stops19h 25m

£620

Flights are sorted by cheapest return flights first.

Deals found on 20/6

Showing 1-10 of 18 resultsSorted by cheapest first
1
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Best time to book a flight from Frankfurt to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Frankfurt with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Frankfurt am Main Airport to Panama City

How far ahead should I book a flight from Frankfurt am Main Airport to Panama City?

To ensure you get the cheapest price possible for a flight from Frankfurt am Main Airport to Panama City, you should look to book at least 11 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Frankfurt am Main Airport to Panama City?

Currently, September is the cheapest month in which you can book a flight from Frankfurt am Main Airport to Panama City (average of £542). Flying from Frankfurt am Main Airport to Panama City in June is currently the most expensive (average of £708). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Frankfurt am Main Airport to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Frankfurt to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Frankfurt am Main?

    For a flight from Frankfurt am Main to Panama City, you will be flying into Tocumen Intl. Panama City Tocumen Intl (PTY) is just 11.4 mi from the center of the city. Tocumen Intl is the only Panama City airport and it handles 0 inbound flights from Frankfurt am Main per day. 0 airlines have flights to Panama City Tocumen Intl from Frankfurt am Main on a regular basis.

  • How long is the flight from Frankfurt am Main Airport to Panama City?

    Departing from Frankfurt am Main Airport to Panama City will take you 27h 19m. Airlines will cover a distance of 5644 mi.

  • Can I find deals for flights from Frankfurt to Panama City that include hotel bookings?

    Yes. In addition to deals on Frankfurt to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Frankfurt to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Frankfurt to Panama City.

  • Can I find deals for business class flights from Frankfurt to Panama City?

    Yes. Cheapflights offers flight deals from Frankfurt to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Frankfurt am Main Airport to Panama City?

    Currently, September is the cheapest month in which you can book a flight from Frankfurt am Main Airport to Panama City (average of £542). Flying from Frankfurt am Main Airport to Panama City in June is currently the most expensive (average of £708). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

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Why should you use Cheapflights to find cheap flight tickets from Frankfurt to Panama City?

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Yes! Cheapflights helps users easily find flights from Frankfurt to Panama City with no change fees.

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Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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