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Cheap flights from Prague to San Francisco from £348

PRG — SFO
11 Oct — 18 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Prague to San Francisco

Enter your travel dates to find the best prices.

Cheapest flights from Prague to San Francisco

Wed 7/1014:30 -
1 stop30h 15m
Thu 12/1107:00 -
2 stops19h 10m
Deal found 11/9£417
Mon 2/1114:30 -
1 stop30h 15m
Tue 17/1106:00 -
2 stops20h 10m
Deal found 10/9£418
Tue 6/1011:00 -
1 stop18h 06m
Tue 13/1009:54 -
2 stops20h 06m
Deal found 7/9£420
Thu 8/1006:00 -
1 stop14h 45m
Thu 22/1012:08 -
2 stops20h 32m
Deal found 7/9£422
Thu 1/1011:40 -
1 stop15h 20m
Wed 4/1111:45 -
2 stops20h 20m
Deal found 7/9£423
Tue 29/910:15 -
1 stop21h 41m
Wed 4/1115:07 -
2 stops20h 28m
Deal found 8/9£423
Thu 8/1006:00 -
2 stops26h 20m
Wed 21/1013:55 -
1 stop17h 05m
Deal found 7/9£424
Thu 15/1014:30 -
1 stop14h 20m
Sat 7/1113:40 -
1 stop17h 25m
Deal found 8/9£425
Fri 9/1006:00 -
2 stops20h 05m
Tue 27/1014:50 -
1 stop18h 45m
Deal found 6/9£426
Wed 21/1011:30 -
1 stop17h 20m
Sun 25/1013:50 -
2 stops18h 15m
Deal found 10/9£427

Find flight deals from Prague to San Francisco

Round-trip from

£417

One-way from

£347

Popular in

February

Cheapest in

September

Average price

£422
Delta
  • Delta
  • 7/10-12/11
  • 3 total stops
  • 49h 25m total
  • Prague to San Francisco
Search Deals
3/11-31/12
  • 3/11-31/12
  • 1 total stop
  • 33h 00m total
  • Prague to San Francisco
Search Deals
Highest demand for flights based on searches. 3% potential increase in price (£12 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
Search Deals
Average for round-trip flights in September 2026
Search Deals

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Prague to San Francisco that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest return flight

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Wed 4/11

18:30-11:45

1 stop26h 15m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£348

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Mon 2/11

18:30-11:45

1 stop26h 15m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£348

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Mon 9/11

11:40-10:40

2 stops32h 00m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£349

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Wed 4/11

11:40-00:43

2 stops22h 03m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£349

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Mon 16/11

06:00-16:14

2 stops19h 14m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£352

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Wed 16/12

06:00-15:40

2 stops18h 40m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£352

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Tue 10/11

18:30-14:55

1 stop29h 25m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£358

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Wed 11/11

06:50-18:45

1 stop20h 55m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£358

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Fri 6/11

18:55-14:55

1 stop29h 00m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£358
Fastest return journey

PragueSan Francisco

PRG Václav Havel Prague - SFO San Francisco

PRGSFO

Václav Havel Prague

Sat 7/11

07:40-14:55

1 stop16h 15m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£358

Flights are sorted by cheapest return flights first.

Deals found on 11/9

Showing 1-10 of 20 resultsSorted by cheapest first
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Best time to book a flight from Prague to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Prague with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Prague to San Francisco

How far ahead should I book a flight from Prague to San Francisco?

The price you pay for your flight from Prague to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 46 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Prague to San Francisco?

Currently, September is the cheapest month in which you can book a flight from Prague to San Francisco (average of £422). Flying from Prague to San Francisco in February is currently the most expensive (average of £571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Prague to San Francisco?

Airfare is typical for this route at the moment.

Prague to San Francisco flights typically cost between £409 and £474 in October.
The cheapest return price found within the last 5 days was £417 on Delta (7 Oct–12 Nov).

Related info for your journey

  • How long is the flight from Prague to San Francisco?

    A quick flight from Prague to San Francisco can take about 30h 15m. Delta provides one of the quickest options available for as low as £417. Prague and San Francisco are separated by a distance of 5822 mi.

  • Can I find deals for flights from Prague to San Francisco that include hotel bookings?

    Yes. In addition to deals on Prague to San Francisco flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Prague to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Prague to San Francisco.

  • Can I find deals for business class flights from Prague to San Francisco?

    Yes. Cheapflights offers flight deals from Prague to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Prague to San Francisco?

    Currently, September is the cheapest month in which you can book a flight from Prague to San Francisco (average of £422). Flying from Prague to San Francisco in February is currently the most expensive (average of £571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
San Bruno
Roseville
Newark
Bodega Bay
Sunnyvale
South San Francisco

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Fly with Cheapflights

How does Cheapflights help users find flights from Prague to San Francisco?

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Why should you use Cheapflights to find cheap flight tickets from Prague to San Francisco?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Prague to San Francisco for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Prague to San Francisco with no change fees?

Certainly. Search results for flights to San Francisco from Prague shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Prague to San Francisco become cheaper?

Not ready to book yet? You can track prices for flights from Prague to San Francisco on Cheapflights with our Price Alert feature and get notified when better prices are available.

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