Cheap flights from Southampton to San Francisco from £378

SOU — SFO
10 Dec — 17 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Southampton to San Francisco

Enter your travel dates to find the best prices.

Cheapest flights from Southampton to San Francisco

Thu 24/1217:35 -
1 stop26h 10m
Thu 31/1208:00 -
2 stops25h 05m
Deal found 8/11£685
Thu 3/1208:40 -
1 stop35h 05m
Fri 11/1223:39 -
2 stops25h 16m
Deal found 8/11£715
Mon 30/1117:45 -
2 stops38h 27m
Wed 16/1212:08 -
2 stops20h 57m
Deal found 8/11£719
Tue 15/1208:40 -
2 stops19h 58m
Tue 22/1222:00 -
2 stops26h 10m
Deal found 7/11£721
Thu 3/1208:40 -
1 stop35h 05m
Thu 10/1213:50 -
1 stop35h 05m
Deal found 8/11£756
Mon 30/1117:45 -
2 stops36h 49m
Mon 14/1213:50 -
1 stop19h 15m
Deal found 8/11£760
Thu 10/1212:25 -
1 stop35h 10m
Thu 17/1207:50 -
2 stops17h 00m
Deal found 9/11£789
Tue 1/1209:20 -
1 stop14h 15m
Mon 14/1217:20 -
1 stop18h 10m
Deal found 8/11£792
Tue 15/1217:35 -
1 stop26h 10m
Thu 24/1222:55 -
2 stops33h 55m
Deal found 7/11£804
Mon 30/1120:00 -
1 stop27h 35m
Sun 13/1217:20 -
1 stop31h 30m
Deal found 8/11£813

Find flight deals from Southampton to San Francisco

Round-trip from

£685

One-way from

£378

Popular in

July

Cheapest in

February

Average price

£507
KLM
  • KLM
  • 24/12-31/12
  • 2 total stops
  • 70h 10m total
  • Southampton to San Francisco
11/1-31/12
  • 11/1-31/12
  • 3 total stops
  • 55h 15m total
  • Southampton to San Francisco
Highest demand for flights based on searches. 11% potential increase in price (£51 potential increase over avg. return price).
Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
Average for round-trip flights in November 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Southampton to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Wed 28/4

09:20-15:50

1 stop14h 30m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£508

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Mon 26/4

09:20-15:50

1 stop14h 30m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£508

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Sun 25/4

09:20-15:50

1 stop14h 30m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£508

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Thu 29/4

09:20-15:50

1 stop14h 30m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£508

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Fri 23/4

09:20-15:50

1 stop14h 30m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£508

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Tue 27/4

09:20-15:50

1 stop14h 30m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£510

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Fri 30/4

09:20-15:50

1 stop14h 30m

San Francisco

Wed 31/12

00:00-09:00

Nonstop0h 00m

£526

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Thu 24/12

08:40-23:58

2 stops23h 18m

San Francisco

Thu 31/12

10:02-17:05

2 stops23h 03m

£689

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Thu 3/12

08:40-11:45

1 stop35h 05m

San Francisco

Fri 11/12

23:39-08:55

2 stops25h 16m

£715

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Mon 30/11

17:45-00:12

2 stops38h 27m

San Francisco

Fri 11/12

22:40-08:55

2 stops26h 15m

£719

Flights are sorted by cheapest return flights first.

Deals found on 9/11

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Best time to book a flight from Southampton to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Southampton with our price prediction graph.
Estimated return price

Related info for your journey

  • How long is the flight from Southampton to San Francisco?

    Delta and British Airways can get you from Southampton to San Francisco in just under 23h 18m. Your travel time can differ by up to 28h 32m. Southampton and San Francisco are separated by a distance of 5349 mi. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Southampton to San Francisco that include hotel bookings?

    Yes. In addition to deals on Southampton to San Francisco flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Southampton to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Southampton to San Francisco.

  • Can I find deals for business class flights from Southampton to San Francisco?

    Yes. Cheapflights offers flight deals from Southampton to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Travelling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
San Bruno
Roseville
Santa Cruz
Newark
Sunnyvale
Bodega Bay

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Alternative routes for Southampton to San Francisco

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It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Southampton to San Francisco.

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Can Cheapflights notify me if prices for flights from Southampton to San Francisco become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to San Francisco from Southampton today and book when prices fit your budget.

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