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Cheap flights from Southampton to San Francisco from £360

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/1. Fares are subject to change and may not be available on all flights or dates of travel.
SOU — SFO
3 Dec — 10 Dec1
1 adult
1 adult, Economy, 0 bags

Find flight deals from Southampton to San Francisco

Enter your travel dates to find the best prices.

Cheapest flights from Southampton to San Francisco
Explore the most affordable flight options available from Southampton to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 3 November 2025.

Thu 4/1218:05SOU - SFO
1 stop25h 45mVirgin Atlantic
Mon 8/1213:55SFO - SOU
1 stop19h 05mVirgin Atlantic
Deal found 3/11£484
Thu 4/1218:05SOU - SFO
1 stop25h 45mKLM
Mon 8/1214:00SFO - SOU
2 stops19h 00mKLM
Deal found 3/11£498
Sun 16/1109:30SOU - SFO
1 stop34h 20mDelta
Wed 11/311:05SFO - SOU
2 stops23h 20mDelta
Deal found 1/11£554
Sun 16/1118:05SOU - SFO
1 stop25h 45mDelta
Tue 10/306:00SFO - SOU
2 stops19h 10mDelta
Deal found 2/11£555
Wed 19/1108:40SOU - SFO
2 stops17h 29mDelta
Sun 8/323:55SFO - SOU
2 stops34h 05mDelta
Deal found 1/11£558
Wed 19/1117:30SOU - SFO
2 stops30h 35mDelta
Tue 10/313:35SFO - SOU
2 stops20h 25mDelta
Deal found 2/11£559
Sun 16/1118:05SOU - SFO
1 stop25h 45mDelta
Thu 12/314:55SFO - SOU
1 stop19h 05mDelta
Deal found 1/11£569
Thu 20/1118:05SOU - SFO
1 stop25h 45mDelta
Tue 10/314:55SFO - SOU
1 stop19h 05mDelta
Deal found 1/11£570
Thu 20/1118:05SOU - SFO
1 stop25h 45mDelta
Sun 8/314:55SFO - SOU
1 stop19h 05mDelta
Deal found 2/11£571
Thu 20/1118:05SOU - SFO
1 stop25h 45mDelta
Thu 12/314:55SFO - SOU
1 stop19h 05mDelta
Deal found 1/11£584
Thu 20/1118:05SOU - SFO
1 stop25h 45mDelta
Fri 13/314:55SFO - SOU
1 stop19h 05mDelta
Deal found 2/11£585

Cheap flight deals from Southampton to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Southampton (SOU) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 3 November 2025.

Round-trip from

£484

One-way from

£360

Popular in

July

Cheapest in

September

Average price

£461
Virgin Atlantic
  • Virgin Atlantic
  • 4/12-8/12
  • 2 total stops
  • 44h 50m total
  • Southampton to San Francisco
Search Deals
21/1
  • 21/1
  • 3 total stops
  • 59h 17m total
  • Southampton to San Francisco
Search Deals
Highest demand for flights based on searches. 14% potential increase in price (£64 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£11 potential savings vs. average return price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Southampton to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 3 November 2025.
Use the filters below to find and compare flights from Southampton to San Francisco that are best for you.

Fly from

Southampton

Fly to

San Francisco

Route

Depart

Return

Price

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Thu 4/12

18:05-11:50

1 stop25h 45m

San Francisco

Mon 8/12

13:55-17:00

1 stop19h 05m

£484

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Thu 4/12

18:05-11:50

1 stop25h 45m

San Francisco

Mon 8/12

14:00-17:00

2 stops19h 00m

£498

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Fri 27/3

17:30-12:50

1 stop26h 20m

San Francisco

Tue 31/3

13:45-17:00

1 stop19h 15m

£503

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Sun 16/11

09:30-11:50

1 stop34h 20m

San Francisco

Wed 11/3

14:55-17:25

1 stop19h 30m

£554

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Tue 18/11

17:30-11:50

1 stop26h 20m

San Francisco

Tue 10/3

11:45-17:00

2 stops22h 15m

£554

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Tue 18/11

17:30-11:50

1 stop26h 20m

San Francisco

Wed 11/3

08:55-17:25

2 stops25h 30m

£554

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Mon 17/11

18:05-11:50

1 stop25h 45m

San Francisco

Tue 10/3

14:55-17:00

1 stop19h 05m

£554

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Wed 21/1

08:55-12:12

3 stops59h 17m

£360

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Wed 21/1

12:25-18:45

2 stops38h 20m

£438

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Sun 7/12

16:05-15:35

1 stop31h 30m

£528

Flights are sorted by cheapest return flights first.

Deals found on 1/11

Showing 1-10 of 14 results
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Best time to book a flight from Southampton to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Southampton with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Southampton to San Francisco

What is the cheapest month to book a flight from Southampton to San Francisco?

Currently, December is the cheapest month in which you can book a flight from Southampton to San Francisco (average of £345). Flying from Southampton to San Francisco in July is currently the most expensive (average of £467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Southampton to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Southampton to San Francisco?

    Virgin Atlantic, KLM, and Delta can get you from Southampton to San Francisco in just under 25h 45m. Your travel time can differ by up to 35m. Southampton and San Francisco are separated by a distance of 5349 mi. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Southampton to San Francisco that include hotel bookings?

    Yes. In addition to deals on Southampton to San Francisco flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Southampton to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Southampton to San Francisco.

  • Can I find deals for business class flights from Southampton to San Francisco?

    Yes. Cheapflights offers flight deals from Southampton to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Southampton to San Francisco?

    Currently, December is the cheapest month in which you can book a flight from Southampton to San Francisco (average of £345). Flying from Southampton to San Francisco in July is currently the most expensive (average of £467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Newark
South San Francisco
San Bruno
Bodega Bay
Pacific Grove

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Alternative routes for Southampton to San Francisco

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Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Southampton to San Francisco?

Cheapflights helps you search for flights from Southampton to San Francisco via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Southampton to San Francisco?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Southampton to San Francisco.

Can Cheapflights find flights from Southampton to San Francisco with no change fees?

Need flexible booking options for your flight to San Francisco from Southampton? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Southampton to San Francisco become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to San Francisco from Southampton today and book when prices fit your budget.

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