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Cheap flights from Manchester to South Carolina from £443

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
MAN — CHS
20 Dec — 27 Dec1
1 adult
1 adult, Economy, 0 bags

Find flight deals from Manchester to South Carolina

Enter your travel dates to find the best prices.

Cheapest flights from Manchester to South Carolina
Explore the most affordable flight options available from Manchester to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 20 November 2025.

Mon 8/1211:05MAN - CHS
2 stops26h 32mMultiple Airlines
Tue 23/1214:59CHS - MAN
1 stop11h 56mMultiple Airlines
Deal found 19/11£706
Mon 8/1206:05MAN - CHS
2 stops15h 41mBritish Airways
Tue 23/1220:06CHS - MAN
2 stops33h 49mBritish Airways
Deal found 19/11£721
Tue 16/1206:20MAN - CLT
3 stops34h 44mMultiple Airlines
Tue 23/1207:00CLT - MAN
3 stops25h 35mMultiple Airlines
Deal found 18/11£765
Fri 5/1212:35MAN - CLT
3 stops35h 35mMultiple Airlines
Fri 12/1213:57CLT - MAN
3 stops27h 53mMultiple Airlines
Deal found 17/11£782
Wed 26/1119:15MAN - CLT
2 stops33h 35mScandinavian Airlines
Tue 9/1210:00CLT - MAN
2 stops18h 30mScandinavian Airlines
Deal found 19/11£793
Wed 26/1119:15MAN - MYR
2 stops33h 29mScandinavian Airlines
Mon 8/1214:40MYR - MAN
2 stops22h 55mScandinavian Airlines
Deal found 19/11£793
Wed 26/1119:15MAN - GSP
2 stops33h 30mScandinavian Airlines
Mon 8/1215:23GSP - MAN
2 stops22h 12mScandinavian Airlines
Deal found 19/11£793
Mon 29/1210:30MAN - CLT
1 stop15h 28mMultiple Airlines
Fri 9/115:45CLT - MAN
2 stops19h 30mMultiple Airlines
Deal found 17/11£813
Mon 1/1220:05MAN - CLT
1 stop24h 50mBritish Airways
Thu 11/1222:50CLT - MAN
1 stop12h 40mBritish Airways
Deal found 17/11£855
Mon 29/1210:30MAN - CLT
1 stop15h 28mMultiple Airlines
Tue 6/117:38CLT - MAN
2 stops36h 07mMultiple Airlines
Deal found 17/11£867
Tue 16/1209:40MAN - CLT
2 stops16h 43mBritish Airways
Tue 23/1218:05CLT - MAN
2 stops17h 25mBritish Airways
Deal found 18/11£870
Fri 26/1213:00MAN - CLT
2 stops37h 20mUnited Airlines
Tue 6/110:44CLT - MAN
2 stops20h 36mUnited Airlines
Deal found 17/11£871

Cheap flight deals from Manchester to South Carolina

Keep the following information in mind while searching for Manchester to South Carolina flight deals. Data was last updated 20 November 2025.

Round-trip from

£558

One-way from

£443

Popular in

August

Cheapest in

February

Average price

£731
9/1-13/1
  • 9/1-13/1
  • 6 total stops
  • 64h 19m total
  • Manchester to South Carolina
Search Deals
6/1
  • 6/1
  • 3 total stops
  • 58h 32m total
  • Manchester to South Carolina
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (£46 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£17 potential savings vs. average return price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Manchester to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 20 November 2025.
Use the filters below to find and compare flights from Manchester to South Carolina that are best for you.

Fly from

Manchester

Fly to

South Carolina

Route

Depart

Return

Price

ManchesterCharlotte

MAN - CLT

MANCLT

Manchester

Fri 9/1

19:15-23:59

3 stops33h 44m

Charlotte Douglas

Tue 13/1

07:00-18:35

3 stops30h 35m

£558

ManchesterCharlotte

MAN - CLT

MANCLT

Manchester

Mon 2/2

19:15-23:06

2 stops32h 51m

Charlotte Douglas

Fri 6/2

16:54-09:30

2 stops35h 36m

£639

ManchesterCharleston

MAN - CHS

MANCHS

Manchester

Thu 22/1

19:15-22:07

2 stops31h 52m

Charleston

Sun 25/1

12:00-18:35

2 stops25h 35m

£642

ManchesterSavannah

MAN - SAV

MANSAV

Manchester

Wed 4/2

19:15-21:04

2 stops30h 49m

Savannah/Hilton Head

Sun 8/2

07:00-09:30

2 stops21h 30m

£642

ManchesterMyrtle Beach

MAN - MYR

MANMYR

Manchester

Thu 19/2

10:30-10:00

1 stop28h 30m

Myrtle Beach Intl

Wed 4/3

09:53-07:35

2 stops16h 42m

£653

ManchesterMyrtle Beach

MAN - MYR

MANMYR

Manchester

Thu 19/2

10:30-10:00

1 stop28h 30m

Myrtle Beach Intl

Tue 3/3

09:53-09:30

2 stops18h 37m

£653

ManchesterMyrtle Beach

MAN - MYR

MANMYR

Manchester

Thu 19/2

10:30-10:00

1 stop28h 30m

Myrtle Beach Intl

Sun 1/3

07:00-07:35

2 stops19h 35m

£672

ManchesterMyrtle Beach

MAN - MYR

MANMYR

Manchester

Wed 18/2

10:25-11:29

1 stop30h 04m

Myrtle Beach Intl

Tue 3/3

09:53-09:30

2 stops18h 37m

£677

ManchesterMyrtle Beach

MAN - MYR

MANMYR

Manchester

Sun 15/2

08:55-18:13

2 stops38h 18m

Myrtle Beach Intl

Wed 4/3

17:40-13:55

2 stops15h 15m

£683

ManchesterMyrtle Beach

MAN - MYR

MANMYR

Manchester

Wed 18/2

09:50-22:59

2 stops18h 09m

Myrtle Beach Intl

Tue 3/3

17:40-16:30

2 stops17h 50m

£683

Flights are sorted by cheapest return flights first.

Deals found on 19/11

Showing 1-10 of 41 results
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Best time to book a flight from Manchester to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Manchester with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Manchester to South Carolina

What is the cheapest month to book a flight from Manchester to South Carolina?

Currently, February is the cheapest month in which you can book a flight from Manchester to South Carolina (average of £533). Flying from Manchester to South Carolina in June is currently the most expensive (average of £643). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAN to SC?

Find hourly flight availability from Manchester to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 20 November 2025.

It’s typically best to fly out from Manchester to South Carolina at midday. Doing so could potentially save you 16% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated 20 November 2025.
See what other customers who have flown with KLM, Finnair, andVirgin Atlantic from Manchester to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.7
Good
1,412 reviews
Check prices

Entertainment

7.1

Boarding

7.8

Food

7.3

Crew

8.4

Comfort

7.7

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
KLM
7.7
Good
1,412 reviews
KLM
7.7
Good
1,412 reviews
Check prices

Entertainment

7.1

Boarding

7.8

Food

7.3

Crew

8.4

Comfort

7.7

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
Finnair
7.6
Good
1,334 reviews
KLM
7.7
Good
1,412 reviews
Check prices

Entertainment

7.1

Boarding

7.8

Food

7.3

Crew

8.4

Comfort

7.7

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
Virgin Atlantic
7.5
Good
673 reviews
KLM
7.7
Good
1,412 reviews
Check prices

Entertainment

7.1

Boarding

7.8

Food

7.3

Crew

8.4

Comfort

7.7

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
Aer Lingus
7.2
Good
1,377 reviews
KLM
7.7
Good
1,412 reviews
Check prices

Entertainment

7.1

Boarding

7.8

Food

7.3

Crew

8.4

Comfort

7.7

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
British Airways
6.7
Okay
7,534 reviews
KLM
7.7
Good
1,412 reviews
Check prices

Entertainment

7.1

Boarding

7.8

Food

7.3

Crew

8.4

Comfort

7.7

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.

Related info for your journey

Find useful and relevant information for your journey from Manchester to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Manchester to South Carolina?

    For a flight from Manchester to South Carolina, you will be flying from Manchester. Manchester (MAN) is just 8.9 mi from the center of the city.

  • How long is the flight from Manchester to South Carolina?

    Scandinavian Airlines, Virgin Atlantic, and Delta can get you from Manchester to South Carolina in just under 13h 04m. Your travel time can differ by up to 19h 47m. Manchester and South Carolina are separated by a distance of 4033 mi. Both multi-stop and direct flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Manchester to South Carolina one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at £650. KLM flights start at £698 while deals on British Airways start at £816 one-way.

  • What are the most popular routes from Manchester to South Carolina?

    While some choose either Manchester - Charleston or Manchester - Greenville, Manchester - Charlotte Douglas is the most popular route from Manchester to South Carolina.

  • Can I find deals for flights from Manchester to South Carolina that include hotel bookings?

    Yes. In addition to deals on Manchester to South Carolina flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Manchester to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to South Carolina.

  • Can I find deals for business class flights from Manchester to South Carolina?

    Yes. Cheapflights offers flight deals from Manchester to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Manchester to South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Manchester to South Carolina (average of £533). Flying from Manchester to South Carolina in June is currently the most expensive (average of £643). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Manchester to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Manchester to South Carolina

Discover the top 6 airlines that operate flights from Manchester to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 20 November 2025.
AirlineCheapestAverageFlexibilityOn-time
FinnairCheapest£524Average£663FlexibilityNo cancel feeOn-time76%
Search Finnair flights
British AirwaysCheapest£556Average£713FlexibilityNo cancel feeOn-time70%
Search British Airways flights
Virgin AtlanticCheapest£580Average£737FlexibilityNo cancel feeOn-time72%
Search Virgin Atlantic flights
KLMCheapest£593Average£826FlexibilityNo cancel feeOn-time75%
Search KLM flights
DeltaCheapest£638Average£786FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
Aer LingusCheapest£802Average£974FlexibilityNo cancel feeOn-timeN/A
Search Aer Lingus flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Manchester to South Carolina?

Deals for Manchester to South Carolina flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Manchester to South Carolina?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Manchester to South Carolina.

Can Cheapflights find flights from Manchester to South Carolina with no change fees?

Yes! Cheapflights helps users easily find flights from Manchester to South Carolina with no change fees.

Can Cheapflights notify me if prices for flights from Manchester to South Carolina become cheaper?

Of course! You can now track prices for flights from Manchester to South Carolina and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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