How long is the flight from Panama City to San Francisco?

Copa Airlines can get you from Panama City to San Francisco in just under 7h 47m. Your travel time will be generally consistent. There are 3318 mi between Panama City and San Francisco. Generally, flights for this route are direct.

Weekly flight availability from Panama City to San Francisco

The most flights from PTY to SFO are scheduled on a Wednesday (3 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 112.0 inches per month. January is typically the wettest month, when rainfall can reach 112.0 mm. July is typically the driest time to visit San Francisco when rainfall is around 0.0 mm.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 17.0 C. Travellers hoping to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 11.0 C).

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers holiday packages that include both flights and hotel.

How can I find direct flights from Panama City to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

Can I find deals for business class flights from Panama City to San Francisco?

Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

£271+ Cheap Flights from Panama City to San Francisco

Cheap flight deals from Panama City to San Francisco

Enter your travel dates to find the best prices.

Cheapest

Best

Direct

Last-minute

One-way

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 19 September 2026.

Tue 17/1112:44 -

Nonstop7h 41m

Fri 27/1119:36 -

Nonstop7h 10m

Deal found 16/9£496

Sat 31/1018:08 -

Nonstop7h 32m

Sun 8/1119:36 -

Nonstop7h 10m

Deal found 18/9£512

Fri 18/1218:31 -

Nonstop7h 46m

Tue 5/119:36 -

Nonstop7h 03m

Deal found 16/9£514

Fri 30/1014:24 -

1 stop11h 32m

Mon 9/1122:59 -

1 stop12h 03m

Deal found 17/9£517

Thu 22/1012:38 -

Nonstop7h 32m

Sun 25/1001:31 -

Nonstop7h 15m

Deal found 17/9£529

Thu 19/1116:41 -

1 stop10h 23m

Sun 29/1123:59 -

1 stop16h 39m

Deal found 16/9£534

Tue 20/1015:30 -

1 stop19h 05m

Fri 23/1000:45 -

1 stop15h 52m

Deal found 15/9£541

Sat 19/1218:31 -

Nonstop7h 46m

Sat 2/119:36 -

Nonstop7h 03m

Deal found 15/9£581

Sun 25/1015:41 -

1 stop17h 47m

Tue 3/1118:42 -

1 stop17h 03m

Deal found 17/9£592

Sat 3/1015:50 -

1 stop10h 05m

Wed 7/1014:15 -

1 stop18h 15m

Deal found 17/9£630

Sat 19/1215:25 -

1 stop11h 33m

Sat 2/108:00 -

1 stop10h 43m

Deal found 15/9£636

Thu 22/1012:38 -

Nonstop7h 32m

Thu 22/1001:12 -

Nonstop7h 15m

Deal found 17/9£637

Find flight deals from Panama City to San Francisco

Round-trip from	£496
One-way from	£271
Popular in	October
Cheapest in	April
Average price	£518

Copa Airlines
26/1-16/2
Nonstop
14h 46m total
Panama City to San Francisco

Search Deals

Copa Airlines
24/11-31/12
Nonstop
7h 41m total
Panama City to San Francisco

Search Deals

Highest demand for flights based on searches. 1% potential increase in price (£7 potential increase over avg. return price).

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Cheapest flight prices on average. 0% potential price decrease (£4 potential savings vs. average return price).

Search Deals

Average for round-trip flights in September 2026

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Sun 22/11

12:44-17:25

Nonstop7h 41m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£271

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Thu 21/1

18:31-23:15

Nonstop7h 44m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£271

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Tue 9/3

18:21-23:05

Nonstop7h 44m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£271

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Wed 18/11

15:29-23:58

1 stop11h 29m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£274

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Sun 31/1

12:40-17:25

Nonstop7h 45m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£289

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Tue 20/10

15:30-14:49

1 stop25h 19m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£292

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Sun 31/1

08:55-23:59

1 stop18h 04m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£326

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Tue 9/3

16:41-07:20

1 stop17h 39m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£327

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Sun 14/2

16:41-07:20

1 stop17h 39m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£331

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Tue 17/11

12:44-17:25

Nonstop7h 41m

San Francisco

Fri 27/11

19:36-05:46

Nonstop7h 10m

£496

Flights are sorted by cheapest return flights first.

Deals found on 14/9

Showing 1-10 of 19 resultsSorted by cheapest first

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

PTY-SFO

Estimated return price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

Prices

Airlines

How far ahead should I book a flight from Panama City to San Francisco?

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 36 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of £458). Flying from Panama City to San Francisco in October is currently the most expensive (average of £605). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

When flying from Panama City to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Panama City to San Francisco?

Airfare is below average for this route at the moment.

Panama City to San Francisco flights typically cost between £496 and £658 in February.
The cheapest return price found within the last 5 days was £496 on Copa Airlines (3 Feb–17 Feb).

Related info for your journey

How long is the flight from Panama City to San Francisco?
Copa Airlines can get you from Panama City to San Francisco in just under 7h 47m. Your travel time will be generally consistent. There are 3318 mi between Panama City and San Francisco. Generally, flights for this route are direct.
Can I find deals for flights from Panama City to San Francisco that include hotel bookings?
Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Panama City to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.
Can I find deals for business class flights from Panama City to San Francisco?
Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to San Francisco?
Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of £458). Flying from Panama City to San Francisco in October is currently the most expensive (average of £605). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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When you search for this flight from Panama City to San Francisco, Cheapflights searches on 900+ travel sites to save you time finding great flight deals online. Additionally, we offer filter features so you can choose a preferred cabin class or airline, see different price ranges, and much more so you can book the flight for you.

Why should you use Cheapflights to find cheap flight tickets from Panama City to San Francisco?

Cheapflights helps you find that perfect flight to San Francisco from Panama City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Panama City to San Francisco with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Panama City to San Francisco, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Panama City to San Francisco become cheaper?

Yes! Start tracking prices for Panama City to San Francisco flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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Cheap flights from Panama City to San Francisco from £271

This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/11. Fares are subject to change and may not be available on all flights or dates of travel.

Cheap flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 19 September 2026.

Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 19 September 2026.

Best flights from Panama City to San FranciscoDiscover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 19 September 2026.

Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 19 September 2026.

Direct flights from Panama City to San FranciscoExplore direct flight options from Panama City to San Francisco based on user searches, and compare prices and availability for your desired travel dates. Data last updated 19 September 2026.

Explore direct flight options from Panama City to San Francisco based on user searches, and compare prices and availability for your desired travel dates. Data last updated 19 September 2026.

Last-minute flights from Panama City to San FranciscoDiscover last-minute flight deals from Panama City to San Francisco. Data last updated 19 September 2026 and is based on user searches.

Discover last-minute flight deals from Panama City to San Francisco. Data last updated 19 September 2026 and is based on user searches.

One-way flights from Panama City to San FranciscoSearch for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated 19 September 2026.

Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated 19 September 2026.

Find flight deals from Panama City to San Francisco

Round-trip from

One-way from

Popular in

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Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Cheapflights Insights

How far ahead should I book a flight from Panama City to San Francisco?

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 36 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

What is the cheapest time of day to fly from PTY to SFO?

When flying from Panama City to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Panama City to San Francisco?

Airfare is below average for this route at the moment.

Panama City to San Francisco flights typically cost between £496 and £658 in February.The cheapest return price found within the last 5 days was £496 on Copa Airlines (3 Feb–17 Feb).

Weekly flight availability from Panama City to San Francisco

The most flights from PTY to SFO are scheduled on a Wednesday (3 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

Related info for your journey

How long is the flight from Panama City to San Francisco?

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

How can I find direct flights from Panama City to San Francisco?

Can I find deals for business class flights from Panama City to San Francisco?

What is the cheapest month to book a flight from Panama City to San Francisco?

Travelling to a place near San Francisco?

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Complete your trip

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Panama City and San Francisco flights

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How does Cheapflights help users find flights from Panama City to San Francisco?

Why should you use Cheapflights to find cheap flight tickets from Panama City to San Francisco?

Can Cheapflights find flights from Panama City to San Francisco with no change fees?

Can Cheapflights notify me if prices for flights from Panama City to San Francisco become cheaper?

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Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 19 September 2026.

Best flights from Panama City to San Francisco
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 19 September 2026.

Direct flights from Panama City to San Francisco
Explore direct flight options from Panama City to San Francisco based on user searches, and compare prices and availability for your desired travel dates. Data last updated 19 September 2026.

Last-minute flights from Panama City to San Francisco
Discover last-minute flight deals from Panama City to San Francisco. Data last updated 19 September 2026 and is based on user searches.

One-way flights from Panama City to San Francisco
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated 19 September 2026.

Panama City to San Francisco flights typically cost between £496 and £658 in February.
The cheapest return price found within the last 5 days was £496 on Copa Airlines (3 Feb–17 Feb).